Complement-mediated bactericidal activity of anti- factor H binding protein monoclonal antibodies against the meningococcus relies upon blocking factor H binding. Binding of the complement-downregulating protein factor H fH to the surface of the meningococcus is important for survival of the organism in human serum. The meningococcal vaccine candidate factor H binding protein fHbp is an important ligand for human fH. While some fHbp-specific monoclonal antibodies MAbs block binding of fH to fHbp, the stoichiometry of blocking in the presence of high serum concentrations of fH and its effect on complement-mediated bactericidal activity are unknown.
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Michael A. Gonzales Longreads January 13 minutes 3, words. Last October, when it was announced that the SoHo bookstore McNally Jackson would moving in June, from its Prince Street location after 14 years a decision that now seems to have been reversed , two people immediately came to mind: genius artist David Bowie, who in his lifetime was a frequent customer, and my late buddy Brook Stephenson, who worked at the shop for 11 years before his sudden passing on August 8, Later I heard he had been dancing when he suddenly collapsed, foiled by an unknown heart problem. It was early Sunday morning when I heard the bad news from photographer Marcia Wilson. Although Marcia and I were friends, we rarely spoke on the phone, so my Spidey sense began tingling the moment I peeped her name on the caller ID. Read more….
But what was just a worry turned into a nightmare the other day when I read Getting Real, a collection of essays on the sexualisation of girlhood. I was aware of the dangers of Barbie dolls and body image, but I was not aware of the recent research showing that all boys have seen pornography by the age of And girls are now "into" pornography at an alarmingly early age.
Development of sexuality is an integral part of the development and maturation of children. A range of sensational, emotional and consequent sexual activities that may occur before or during early puberty, but before full sexual maturity is established. The development of child sexuality is influenced by social and cultural aspects; the perception of developing child sexuality is even more heavily influenced by cultural aspects. The concept of child sexuality also played an important role in the classical psychoanalysis. Human evolution of social systems seems to favor nurture kinship relations between adults and children, which implies cultures intended to protect children from harm. In Western Europe , the predominant religion was Catholicism and theologians such as Bishop Augustine of Hippo considered orgasm a sin.